Associate Scientist III, Protein Characterization
Company: Adverum Biotechnologies
Location: Redwood City
Posted on: October 18, 2024
Job Description:
Redwood City, CA Assay Development Full Time Protein
Characterization Associate Scientist III will report to
Director-level personnel in Assay Development to support Quality
Control, Process Development, and other CMC departments. This role
is responsible for building, optimizing, and maintaining
chromatographic and biophysical assays in support of gene therapy
product release and characterization. This role is expected to be
at least 80% on site at our Redwood City location and at most 20%
remote. What you'll do:
- Lead development, qualification, validation, and transfer of
chromatographic and biophysical assays in some or all following
categories: 1) Chromatography, including SEC, AEX, RP, and AF4 2)
Light scattering applications, including DLS and MALS 3) Capillary
electrophoresis, including CE-SDS, CE-LIF, and icIEF 4) Mass
spectrometry applications, including intact LC-MS, peptide-mapping
LC-MS/MS, and quantitative LC-MS/MS with MRM
- Lead conception, design, and execution of robustness
testing
- Lead pilot forced degradation projects
- Lead transfer of processes, technology, and assays to/from
internal and external labs
- Oversee assay development, testing, and troubleshooting at
internal and external labs
- Evaluate, implement, and optimize new technology within Assay
Development to support product extended characterization
- Present results, conclusions, and implications to
cross-functional teams and senior management to support data-driven
decision making
- Participate in external scientific meetings
- Author test procedures, standard test methods, SOPs, protocols,
and technical reports
- Serve as a subject matter expert for chromatographic and
biophysical assays
- Train and mentor junior personnel in technical areas
- Maintain a detailed awareness of industry regulatory guidance
and standards for assay validation and performance
- Maintain current knowledge of advancing technologies and
propose their applications to ongoing projects.
- Maintain excellent documentation of laboratory activities
- Perform routine lab maintenance
- Other responsibilities may be assigned as neededAbout you:
- Associate Scientist: Master's degree with 8+ years or
Bachelor's degree with 10-12 years of relevant biotechnology
industry experience.
- Experience in assay development is required
- Ability to read and extract information from published
literature and internal reports is required
- Expertise is required in some or all of the following
techniques: HPLC, AF4, CE, DLS, and MALS, LC-MS, and LC-MS/MS
- Experience in the qualification/validation of quantitative
assays and knowledge of FDA requirements is strongly desired
- Broad knowledge of protein, cell, or nucleic acid assay methods
and biochemistry with application to gene therapy is strongly
desired
- Experience working with AAVs is a plus.
- Expertise in BLI, DSF, AUC, or BMI is desirable but not
essential.
- Must be a self-starter, proactive, co-operative, and proficient
at working both independently and in a small team environment
- Proven initiative and demonstrated accountability in a
fast-paced environment with high degree of flexibility
- Detail oriented and with time management skills
- Excellent verbal and written communication skills
- Experience in presenting data through written reports and oral
presentation; publication in a peer-reviewed journal or
presentation at a conference is desired
- Proficiency with Empower, Dynamics, Astra, and other common
analytical software desired
- Proficient with MS Office and other common office software
About Us Adverum is a clinical-stage gene therapy company targeting
unmet medical needs in ophthalmology and rare diseases. Adverum
develops gene therapy product candidates designed to provide
durable efficacy by inducing sustained expression of a therapeutic
protein. Adverum's core capabilities include clinical development,
novel vector discovery and in-house manufacturing expertise,
specifically in scalable process development, assay development,
and current Good Manufacturing Practices quality control. At
Adverum, -Inclusion -and -Diversity -are at our core. We believe in
the power of being your authentic self. We strive to create the
space which allows for everyone in our Adverum -Community -to not
only feel safe but encouraged to speak, learn from each other, grow
in their professions and be the very best versions of themselves no
matter what their age, ethnic background, gender, origin, religion
or sexual orientation
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Keywords: Adverum Biotechnologies, Danville , Associate Scientist III, Protein Characterization, Other , Redwood City, California
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